Standardized and modular microfluidic platform for fast Lab on Chip system development

EVEON contributes to microfluidic standards development by participating in the design and use of a modular R&D platform using standardized components. Work on this subject has been published in the magazine Sensors and Actuators B: Chemical.

Abstract : Since the Lab on a Chip concept was introduced in the 1990s, a lot of scientific advancements have occurred. However, large scale commercial realization of microfluidic technology is being prevented by the lack of standardization. There seems to be a gap between Lab on a Chip systems developed in the lab and those that are manufacturable on a large scale in a fab. In this paper, we propose a modular platform which makes use of standardized parts. Using this platform, a functional-based method of designing microfluidic systems is envisioned. To obtain a certain microfluidic function, a bottom-up design is made. This results in micro fluidic building blocks that perform a microfluidic function. This microfluidic building block is then stored in a library, ready for reuse in the future. Key characteristics are shown for several basic microfluidic building blocks, developed according to a footprint and interconnect standard by various players in the microfluidic world. Such a library of reusable and interoperable microfluidic building blocks is important to fill the gap between lab and fab, as it reduces the time-to-market by lowering prototype time cycles. The wide support of key European players active in microfluidics, which is shown by an ISO workshop agreement (IWA 23:2016), makes this approach more likely to succeed compared to earlier attempts in modular microfluidics.

S.Dekkera, W.Buesinkb, M.Blomb, M.Alessiocd, N.Verplanckcd, M.Hihoude, C.Dehane, W.Césarf, A.Le Nelf, A.van den Berga, M.Odijka
a BIOS Lab on Chip Group, MESA+ institute for Nanotechnology, University of Twente, 7500AE, Enschede, Netherlands
b Micronit Microtechnologies B.V., Colloseum 15, 7521PV, Enschede, Netherlands
c Univ. Grenoble Alpes, F-38000 Grenoble, France
d CEA, LETI, MINATEC Campus, F-38054 Grenoble, France
e EVEON, 345 rue Lavoisier, 38330 Montbonnot-Saint-Martin, France
f Fluigent, 1 mail du Professeur Mathé, 94800 Villejuif, France

Sensors and Actuators B: Chemical, Volume 272, 1 November 2018, pp 468-478

More details: 
- On Science Direct website:
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